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Experimental Pharmacology [Ex-Pharm] Series   (Pharmacology Experiments – Simulation Software)                

What is Experimental Pharmacology Series (Ex Pharm Series)

This is a computer assisted learning (CAL) package containing various programs which simulate animal experiments in Pharmacology. These programs can be used to demonstrate drug on different animals systems. The package is user friendly, highly interactive and full of animated sequences which make simulation appear realistic. The current version of Experimental Pharmacology Series (Ex-Pharm series) Software consists of following computer simulated experiments:

 



Experiments List



 

01. Experiment on effects of various drugs (Mydriatic, Miotic and Local Anaesthetic) on rabbit's eye.

 

     - Epinephrine

 

     - Atropine

 

     - Ephedrine

 

     - Physostigmine

 

     - Lignocaine

 

02. Study of Analgesic activity with the help of "Tail Flick Apparatus" (Analgesiometer).

 

03. Study of Analgesic activity with the help of "Hot Plate Apparatus" (Analgesiometer).

 

04. To study analgesic activity by writhing test.

 

05. Study of Antihistaminic drugs/Anti allergic drugs by mast cell stabilization method with help of "Histamine          Chamber”

 

06. Study of Muscle Relaxant activity with the help of "Rota-Rod Apparatus".

 

07  Study of CNS Depressants & Stimulants Using "Actophotometer".

 

08. Study of Drugs acting on CNS (Including Anxiolytic Activity) using following modules

 

      - Elevated Plus Maze Method

 

      - Pole Climbing Method

 

09. Study of anticonvulsant activity using "Electro Convulsiometer".

 

10. To study PTZ induced convulsions in mice

 

11. Simulation of pupil control

 

      - Simulation of the effects of the physiological stimuli and drugs on the papillary reflexes.

 

      - Simulation of the control in patient with partial parasymathectomy.

 

12. Experiments on Lagendorff’s Apparatus

 

      - Effect of coronary vasodilators on isolated heart

 

      - Effect of parasympathomimetics

 

13. Test for pyrogens using rabbits.

 

14. Effect of drugs on isolated guinea pig ileum (in-vitro).

 

15. To study respiratory depression effect on rabbit.

 

16. Study of stereotype and anti-catatonic activity of drugs on mice.

 

17. Experiments on thyroid and antithyroid drugs

 

      - The effect of thyroxin, TSH, propylthiouracil, on metabolism.

 

18. Experiments on blood sugar

 

      -  The effect of insulin (hypoglycemic activity) and alloxan on blood glucose.

 

18. Study of anti-inflammatory activity using carrageenan induced paw oedema method

 

20. Study of diuretic activity using metabolic cage

 

21. Experiment on Effect of various drugs on Isolated Frog's Heart. (DRC- Dose Response Curve)

 

     - Epinephrine

 

     - Norepinephrine

 

     - Isopreneline

 

     - Calcium Chloride

 

     - Prapanolol

 

     - Actyelcholine

 

     - Potassium chloride

 

     - Atropine sulphate

 

22. Experiment on Bioassay of Histamine on the Ileum of Guinea Pig.

 

23. To study the action of strychnine/ anaesthetic on frog neurons (excitability). 

 

24. Experiments on effect of different drugs on dog BP & heart rate.

 

      - The Effect of epinephrine, acetylcholine, atropine on the arterial pressure (dog-blood pressure).

      - Simultaneous analysis of effect of different drugs on dog heart rate and blood pressure.

      - Effects of drugs on blood pressure (vasopressor and vaso-depressors with appropriate blockers.

 

25. Bioassay of Acetylcholine on the isolated rectus abdominis muscle of frog

 

        (a) By Matching Method,  (b) By Interpolation Method,   (c) By 3 Point Method,   (d) By 4 Point Method.

 

26. Bioassay of oxytocin on the isolated rat uterine horn by following methods

 

        (a) By Matching Method,  (b) By Interpolation Method,   (c) By 3 Point Method,   (d) By 4 Point Method.

 

27. Bioassay of serotonin on the isolated rat fundus strip by following methods

 

        (a) By Matching Method,  (b) By Interpolation Method,   (c) By 3 Point Method,   (d) By 4 Point Method.

 

28. To record the DRC and to determine the PD2 value for acetylcholine on frog rectus abdominis muscle.

 

29. Study of anti-ulcer activity - using pylorus ligation method.

 

30. Evaluation of effect of acetylcholine (spasmogens) using rabbit jejunum

 

31. Evaluation of effect of different drugs on ciliary motility.

 

32. Evaluation of effect of saline purgatives on frog intestine.

 

33. Determination of acute irritation of a test substance.

 

      - Skin irritation (Including edema formation)

 

      - Eye irritation

 

 

For whom is the software?

Software is aimed for medical, pharmacy and dental undergraduate students. The software can also be used by the students of paramedical courses such as nursing, medical laboratory technology and physiotherapy etc.


Why it is Necessary:

As per National Medical Commission, 
NMC has issued MSR for Medical Colleges through Gazette Notification, Dated 29 Oct 2020. The mentioned regulations has stated that pharmacology experiments should be done by computer assisted learning software (Please see page number 64 & 75).

As per Medical Council of India, 

MCI has issued guidelines through Gazette Notification No. MCI-34(41)/2013-Med./64022; Dated 19 March 2014. The mentioned guidelines has stated that “For teaching Physiology and Pharmacology in UG curriculum, the required knowledge and skills should be imparted by using Computer Assisted modules”.

As per Pharmacy Council of India

a. PCI has issued guidelines through Gazette Notification No.10-1/2012- PCI; Dated 25 August 2014. The mentioned guidelines has stated that “Wherever animal experimentations are prescribed in the curriculum, the required knowledge and skill should be imparted by using computer assisted modules”.

b. PCI (Pharmacy council of India) has issued the latest notification, Dated : 25 Nov 2019, Ref. No: 10-1/2019-PCI (PT-  1)/6644-46 (Letter Attached) as per that " Wherever animal experiments are being conducted using simulations, the requirement of Animal House & registration with CPCSEA is not Required for such institutions"


c  PCI - Proposed Amendment Notification in Education Regulation - Recommending Ex Pharm Software (See Page No: 33- Point 5)

As per Central Council of Indian Medicine 

The Latest CCIM Syllabus for Post graduate Course in Ayurved has  Recommended Experimental Pharmacology Software as Recommended Material in Point No: 12(14) of Drug Research & Development Recommended tools. This software also covers the syllabus of point number - 5 of 1st YR syllabus of research methodology.

Subscription Procedure:

1. The software can be subscribed by filling online subscription form.

2. The software can also be subscribed by sending the filled subscription form

    with the requisite fees (as mentioned in form), on below mentioned address.



    Address:

    Health Education Bureau, 55/20, Rajat Path, Mansarovar, Jaipur,

    Rajasthan,PIN-302020.

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